J. Cesar Cardenas
Ph.D. In Biomedical Science, Universidad de Chile.
I earned my Ph.D. from the University of Chile, where I studied the mechanism that regulated nuclear Ca2+ under Dr. Enrique Jaimovich’s mentoring. Then I moved to the University of Pennsylvania Medical School where I explored the nuclear localization 1,4,5-trisphosphate receptor (InsP3R) Ca2+channel by using high resolution electron microscopy and cryofracture as a postdoctoral fellow with Dr. Clara Franzini-Armstrong. Motivate in gain a better understanding of the physiological role of the InsP3R I joined Dr. Kevin Foskett’s lab also at UPENN, where I developed a strong interest in the regulation of cellular metabolism and bioenergetics by Ca2+. I was the first to show that basal constitutive low-level Ca2+ signaling by the InsP3R, is essential to maintain the sufficient mitochondrial NADH production to support oxidative phosphorylation in resting cells. In the absence of this calcium signaling, cells become metabolically compromised and a pro-survival AMPK-dependent mTOR-independent autophagy is turned on.
In 2019 I joined the Center of Integrative Biology at Universidad Mayor where we are exploring the role of mitochondrial-endoplasmic reticulum communication in cancer and aging .
Hernan Huerta
JAIN Foundation Postdoctoral Fellow
Biochemist from the Universidad de Santiago de Chile and PhD in Biomedical Sciences from Universidad de Chile. At present I’m studying the role of ketones in dysferlinopathy and soon I expect to publish my work in ketones, cellular senescence and it impact in cancer.
Pablo Morgado
PhD student
Master in Biochemistry and Biochemist from the Universidad de Chile with vast knowledge in flow cytometry, microbiology and molecular biology techniques. At present he is a student in the Biochemist PhD program at Universidad de Chile and is interested in determine the role of mitochondrial dynamics in the establishment of cellular senescence.
Cesar Casanova
Ph.D Student
Phonoaudiologist from the Universidad de Chile, Master in University Pedagogy and Public Health from Universidad Mayor and Master in Craniocervical and Craniomandibular Physiopathology and Facial Pain from Universidad Andres Bello. At present is student in the Neurobiology Ph.D program at Universidad Mayor and is interested in senescence escape after chemotherapy in glioblastoma and the role of glutamine.
Andrea Puebla
Undergraduate student
Biochemistry student from Universidad de Chile. Her Thesis focus in determine the role of mitochondrial calcium uptake (MCU) complex in cellular senescence
Past Members
Osman Diaz
Research Assistant
Biotechnologist from Universidad de Chile working on mitohormesis
John Doe
UpSolution Team