Mitochondrial division inhibitor-1 (mdivi-1) induces extracellular matrix (ECM)-detachment of viable breast cancer cells by a DRP1-independent mechanism. Eduardo Silva-Pavez, Elizabeth Mendoza, Pablo Morgado, Ulises Ahumada-Castro, Galdo Bustos, Matías Kangme-Encalada, Amaia Lopez de Arbina, Andrea Puebla-Huerta, Felipe Muñoz, Lucas Cereceda, Manuel Varas-Godoy, Yessia Hidalgo, and J. César Cárdenas. 14(1):14178. 2024.

Ketogenic diet administration later in life improves memory and regulates the synaptic cortical proteome through the cAMP/PKA signaling pathway in aging mice. Diego Acuña-Catalán, Samah Shah, Cameron Wehrfritz, Mitsunori Nomura, Alejandro Acevedo, Cristina Olmos, Gabriel Quiroz, Hernán Huerta, Joanna Bons, Estibaliz Ampuero, Ursula Wyneken, Magdalena Sanhueza, Felipe Arancibia, Darwin Contreras, Julio César Cárdenas, Bernardo Morales, Birgit Schilling, John C. Newman and Christian González-Billault. Cell Reports Medicine. 5(6):101593. 2024.

Functional selectivity of estradiol or phytoestrogens in membrane estrogen receptors of endothelial cells; fast NO production associated to vasorelaxation. Vicente Catalán, Pablo Sagredo, Williams Melgarejo, J. Cesar Cárdenas, Armen Zakarian, Verónica Donoso, J. Pablo Huidobro-Toro. European Journal of Pharmacology. 975:176636. 2024.

Functional selectivity of estradiol or phytoestrogens in membrane estrogen receptors of endothelial cells; fast NO production associated to vasorelaxation. Vicente Catalán, Pablo Sagredo, Williams Melgarejo, J. Cesar Cárdenas, Armen Zakarian, Verónica Donoso, J. Pablo Huidobro-Toro. European Journal of Pharmacology. 975:176636. 2024.

Impact of platelet-released mitochondria transfer in the metabolic profiling and progression of metastatic MDA-MB-231 human triplenegative breast cancer cells. Lucas Cereceda, Cesar Cardenas, Maroun Khoury, Eduardo Silva-Pavez, Yessia

Hidalgo. Frontiers in Cell and Developmental Biology. 11:1324158. 2024.

Sustained IP3-linked Ca2+ signaling promotes progression of triple negative breast cancer cells by regulating fatty acid metabolism. Filadi R, De Mario A, Audano M, Romani P, Pedretti S, Cardenas C, Dupont S, Mammucari C, Mitro N, Pizzo P. Front Cell Dev Biol. 11:1071037. 2023.

Necroptosis inhibition counteracts axonal degeneration, cognitive decline and key hallmarks of aging, promoting brain rejuvenation. Macarena S. Arrázola, Matías Lira,  Gabriel Quiroz, Somya Iqbal, Samantha L Eaton, Rachel A Kline, Douglas J Lamont, Hernán Huerta,  Gonzalo Ureta, Sebastián Bernales, J César Cárdenas,  Waldo Cerpa,  Thomas M. Wishart,  Felipe A. Court. Aging Cell. e13814. 2023

Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging. Cabral-Miranda F, Tamburini G, Martinez G, Ardiles AO, Medinas DB, Gerakis Y, Hung MD, Vidal R, Fuentealba M, Miedema T, Duran-Aniotz C, Diaz J, Ibaceta-Gonzalez C, Sabusap CM, Bermedo-Garcia F, Mujica P, Adamson S, Vitangcol K, Huerta H, Zhang X, Nakamura T, Sardi SP, Lipton SA, Kennedy BK, Henriquez JP, Cárdenas JC, Plate L, Palacios AG, Hetz C. EMBO J. e111952. 2022.

Bidirectional distress signalling in the ER to mitochondria contact sites. Amado Carreras-Sureda, Guido Kroemer, Cesar Cardenas and Claudio Hetz. Science Signaling. 15(741): eabm7524. 2022.

A phenolic-rich extract from Ugni molinae berries reduces abnormal protein aggregation in a cellular model of Huntington’s disease. Rodrigo Pérez-Arancibia, Jose Luis Ordoñez, Alexis Rivas, Philippe Pihán, Alfredo Sagredo, Ulises Ahumada, Andrés Barriga, Ivette Seguel, César Cárdenas, Rene L. Vidal, Claudio Hetz, Carla Delporte. PLOS ONE 16(7): e0254834. 2021.

Directly Reprogrammed Human Neurons to Understand Age-Related Energy Metabolism Impairment and Mitochondrial Dysfunction in Healthy Aging and Neurodegeneration. Camila Gudenschwager, Isadora Chavez, Cesar Cardenas and Christian Gonzalez-Billault. Oxidative Medicine and Cellular Longevity, 5586052. 2021.

Keeping zombies alive: The ER-mitochondria Ca2+ transfer in cellular senescence. Ahumada-Castro U, Puebla-Huerta A, Cuevas-Espinoza V, Lovy A, Cardenas JC. Biochim Biophys Acta Mol Cell Res.1868(11):119099. 2021.

Cdkn1a transcript variant 2 is a marker of aging and cellular senescence. López-Domínguez JA, Rodríguez-López S, Ahumada-Castro U, Desprez PY , Konovalenko M, Laberge RM, Cárdenas C, Villalba JM & Campisi J. Aging. 13 (10):13380-13392. 2021

The ER-mitochondria Ca2 + signaling in cancer progression: Fueling the monster

Galdo Bustos, Ulises Ahumada-Castro, Eduardo Silva-Pavez, Andrea Puebla, Alenka Lovy, J. Cesar Cardenas. International Review of Cell and Molecular Biology. 363:49-121. 2021.

Scalable Total Synthesis, IP3R Inhibitory Activity of Desmethylxestospongin B, and Effect on Mitochondrial Function and Cancer Cell Survival. Maša Podunavac, Artur Mailyan, Jeffrey, J. Jackson, Alenka Lovy, Paula Farias, Hernan Huerta, Jordi Molgó, Cesar Cardenas, Armen Zakarian. Angew Chem Int Ed Engl. 60(20):11278-11282. 2021.

CD73 Ectonucleotidase Restrains CD8+ T Cell Metabolic Fitness and Anti-tumoral Activity. Briceño P, Rivas-Yañez E, Rosemblatt MV, Parra-Tello B, Farías P, Vargas L, Simon V, Cárdenas C, Lladser A, Salazar-Onfray F, Elorza AA, Rosemblatt M, Bono MR, Sauma D. Front Cell Dev Biol. 9:638037. 2021

Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition). Klyonsky et al…Cardenas C., Autophagy. (1):1-382. 2021.

Ca2+ transfer to mitochondria: a spark of life in unexpected conditions.

Silva-Pavez E, Ahumada-Castro U, Lovy A, Cárdenas JC. Mol Cell Oncol. 8(1):1839341. 2021.

In the right place at the right time: IP3 Receptor isoforms differentially controlling cellular metabolism Ulises Ahumada-Castro, Galdo Bustos, Eduardo Silva-Pavez, Andrea Puebla-Huerta, Alenka Lovy and César Cárdenas. Front Cell Dev Biol. 2;9:629522. 2021.

Inhibition of InsP3R with Xestospongin B reduces mitochondrial respiration and induces selective cell death in T cell acute lymphoblastic leukemia cells Pablo Cruz, Ulises Ahumada-Castro, Galdo Bustos, Jordi Molgó, Daniela Sauma, Alenka Lovy and César Cárdenas. Int J Mol Sci. 2021. 22(2):651.

Reduced mitochondrial function in idiopathic inflammatory myopathy derived myoblast is a metabolic adaptation to promote cell survival. Basualto-Alarcón, C., Urra, F.A., Bozán, M.F., Jaña, F., Trangulao, A., Bevilacqua, J.A., Cárdenas, C. PLOS ONE. 15(11):e0242443. 2020.

Concerted action of AMPK and sirtuin-1 induces mitochondrial fragmentation upon inhibition of Ca2+ transfer to mitochondria. Lovy, A., Ahumada-Castro, U., Bustos, G., Farias P., Molgo, J., and Cardenas C. Frontiers in Cell Developmental Biology. 8:378. 2020.

Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival. Cardenas C., Lovy A., Silva-Pavez E., Urra F., Mizzoni C., Ahumada-Castro U., Bustos G., Jaňa F., Cruz P., Farias P., Mendoza E., Huerta H., Murgas P., Hunter M., Rios M., Cerda O., Georgakoudi I., Zakarian A., Molgó J., and Foskett JK. Science Signaling. 13(640):eaay1212. 2020.

SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells. Krabbendam IE, Honrath B, Bothof L, Silva-Pavez E, Huerta H, Peñaranda Fajardo NM, Dekker F, Schmidt M, Culmsee C, Cárdenas C, Kruyt F, Dolga AM.

Biochem Pharmacol. 171:113714. 2020.

Complex I and II Regulate Mitochondrial Ca2+ Homeostasis Independent of the Mitochondrial Membrane Potential. Jaňa, F., Bustos, G., Cruz, P., Lovy, A., Dong, Z., Madesh, M., and Cardenas, C. Mitochondrion.13;49:73-82. 2019

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics.  Carreras-Sureda, A., Jaña, F., Ramos-Fernández, E., Urra, H., Van der Viett, A., Durand, S., Mortenson, D., Pihan, P., Gonzalez-Quiroz, M., Vicente, R., Inestrosa, N., Wiseman, L., Agostinis, P., Bultynck, G., Court, F., Kroemer, G., Cárdenas, C., and Hetz, C. Nature Cell Biology. 21(6):755-767. 2019

Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep. Gonzalez-Candia A, Veliz M, Carrasco-Pozo C, Castillo RL, Cárdenas JC, Ebensperger G, Reyes RV, Llanos AJ, Herrera EA. Redox Biology. 22: 101128. 2019.

MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells. Ahumada-Castro, U., Silva-Pavez, E., Pardo, E., Lovy, A., and Cárdenas, C. Autophagy. 15(2):358-361, 2019

FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway. Urra FA, Muñoz F, Córdova-Delgado M, Ramírez MP, Peña-Ahumada B, Rios M, Cruz P, Ahumada-Castro U, Bustos G, Silva-Pavez E, Pulgar R, Morales D, Varela D, Millas-Vargas JP, Retamal E, Ramírez-Rodríguez O, Pessoa-Mahana H, Pavani M, Ferreira J, Cárdenas C, Araya-Maturana R. Scientific Report. 8(1):13190, 2018

Mitochondrial Regulation by Calcium as Basis of Neurodegeneration Associated to Aging. Müller, M., Ahumada-Castro, U., Gonzalez-Billault, C., Court, F.A., and Cárdenas, C. Frontiers in Neuroscience. 12:470, 2018

Hepatic Glutaminase activity and glutamine flux contributes to glucagon-stimulated gluconeogenesis and systemic glucose homeostasis. Miller, R.A., Shi, Y., Lu,W.,  Pirman, D.A., Jatkar, A., Blatnik, M., Wu, H., Cárdenas, C., Wan, M., Foskett, J.K.,  Park, J.O., Zhang, Y., Holland, W.L., Rabinowitz, J.D., Birnbaum, M.J. Nature Medicine. 24(4):518-524, 2018.

Mouse Tc17 cells display memory T cell-like traits. Flores-Santibáñez, F., Cuadra, B., Fernández, D., Rosemblatt, M., Núñez, S., Cruz, P., Gálvez-Cancino, F., Cárdenas, C., Lladser, A., Rosemblatt, M., Bono, M.R., and Sauma, D. Frontiers Immunology. 9:209, 2018.

Editorial: Inter- Organelle Calcium Communication in Cancer. Cardenas, C., Pinton, P., and Bultynck, G. Frontiers in Oncology. 8:14, 2018.

Calcium and Mitochondrial Metabolism in Cancer, a Novel Potential Target? Bustos, G., Cruz, P., Lovy, A., and Cárdenas C. Frontiers in Oncology. 7:199, 2017.

The mitochondrial complex(I)ty of cancer. Urra, FA., Muñoz, F., Lovy, A., Cárdenas, C. Frontiers in Oncology. 7:118, 2017.

Diabetic concentrations of Metformin inhibit platelet-mediated ovarian cancer cell

progression. Erices, R., Cubillos, S., Aravena, R., Santoro, F., Marquez, M., Orellana, R., Ramírez, C., González, P., Fuenzalida, P., Bravo, ML., Oliva, B., Kato, S., Ibañez, C., Brañes, J., Bravo, E., Alonso, C., García, K., Arab, C., Torres, VA., Godoy, A., Pereira, J., Bustos, G., Cardenas, C., Cuello, MA., and Owen, GI. Oncotarget. 8 (13): 20865-20880, 2017.

The Paraguayan Rhinella toad venom: Implications in the traditional medicine and proliferation of breast cancer cells. Schmeda-Hirschmann, G., Gomez, CV., de Arias, AR., Burgos-Edwards, A., Alfonso J., Rolon, M., Brusquetti, F., Netto, F., Urra, FA., Cárdenas, C. J Ethnopharmacology. 199: 106–118, 2017.

Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells. Cataldo, L., Mizgier, ML., Bravo, R., Jaña F., Cardenas, C., Llanos, P., Olmos PR., Galgani JE., Santos JL. and Cortés VA. PLOS One. 12(1):e0170213, 2017.

Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura: Bufonidae). Schmeda-Hirschmann, G., Quispe, C., Arana, GV., Theoduloz, C., Urra, FA. and Cárdenas C. Toxicon. 121:119-129, 2016.

InsP3R, the Calcium Whisperer: Maintaining Mitochondrial Function in Cancer. Lovy, A. Foskett, J.K. and Cardenas C. Molecular Cellular Oncology. 3(4):e1185563. 2016

Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria. Cardenas, C., Muller, M, McNeal, A., Lovy, A., Jaňa, F., Bustos, G., Smith, N., Molgo, J., Diehl, A., Ridky, TW., and Foskett J.K. Cell Rep. 14(10):2313-24. 2016

Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson’s disease. Herrera A., Muñoz, P., Paris, I., Díaz-Veliz, G., Mora, S., Inzunza, J., Hultenby, K., Cardenas, C., Jaña, F., Raisman-Vozari, R., Gysling, K., Abarca, J., Steinbusch, HW. and Segura-Aguilar, J. Cell Mol Life Sci. 73(18):3583-972016, 2016

Constitutive activation of CREB by Alzheimer’s disease presenilin-driven InsP₃R Ca²⁺ signaling. Müller, M., Cárdenas, C., Cheung, K.H.  Mei, L., and Foskett, J.K. Proc Natl Acad Sci U S A. 108:13293-13298, 2011.

Structural evidence for perinuclear calcium microdomains in cardiac myocytes. Escobar, M., Cárdenas, C., Colavita, K., Petrenko, N.B. and Franzini-Armstrong. C. J. Mol Cell Car. 50:451-459, 2011.

LETM1-dependent mitochondrial Ca²⁺ flux modulates cellular bioenergetics and proliferation. Doonan, P.J., Chandramoorthy, H.C., Hoffman, N.E., Zhang X., Cárdenas, C., Shanmughapriya, S., Rajan, S., Vallem S., Mallilankaraman, K., Chen, X., Foskett, J.K., Cheung J.Y., Houser, S.R., and Madesh, M.  FASEB J. 28(11):4936-49, 2014.

MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca²⁺ uptake that regulates cell survival. Mallilankaraman, K¹., Doonan, P¹., Cárdenas, C¹., Chandramoorthy, Müller, M., Miller, R., H.C., Hoffman, N.E., Gandhirajan, R., Molgó, J., Birnbaum, M., Rothberg, B., Mak, D., Foskett, J.K. and Madesh, M. Cell 151:630-644, 2012. ¹These authors contributed equally to this manuscript.

MCUR1 is an essential component of mitochondrial Ca²⁺ uptake that regulates cellular metabolism.  Mallilankaraman, K., Cárdenas, C., Doonan, P., Irrinki, K.M., Chandramoorthy, H.C., Madireddi, P., Yang, Y., Miller, R., Molgó, J., Kaufman, B., Foskett, J.K. and Madesh, M. Nature Cell Biol. 12:1336-1343, 2012.

Mitochondrial Ca²⁺ signals in autophagy. Cárdenas, C., and Foskett, J.K Cell Calcium 52: 44-51, 2012.

Constitutive activation of CREB by Alzheimer’s disease presenilin-driven InsP₃R Ca²⁺ signaling. Müller, M., Cárdenas, C., Cheung, K.H.  Mei, L., and Foskett, J.K. Proc Natl Acad Sci U S A. 108:13293-13298, 2011.

Structural evidence for perinuclear calcium microdomains in cardiac myocytes. Escobar, M., Cárdenas, C., Colavita, K., Petrenko, N.B. and Franzini-Armstrong. C. J. Mol Cell Car. 50:451-459, 2011.

Essential regulation of cell bioenergetics by constitutive InsP₃ receptor Ca²⁺ transfer to mitochondria. Cárdenas, C., Miller, R.A., Smith, I., Bui, T., Molgo, J., Müller, M., Vais, H., Cheung, K.H., Yang, J., Parker, I., Thompson, C., Birnbaum, M., Hallows, K.R. and Foskett J.K. Cell 142:270-283, 2010.

Visualization of inositol 1,4,5-trisphospate receptors on the nuclear envelope outer membrane by deep etching electron microscopy. Cárdenas, C., Escobar, M., Foskett, J.K., and Franzini-Armstrong, C. J. Structural Biology 171:372-381, 2010.

Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy derived cells. Cárdenas, C., Juretić, N., Bevilacqua, J.A., García, I., Figueroa, R., Hartley, R., Taratuto, A.L., Gejman, R., Riveros, N., Molgó J. and Jaimovich  E. FASEB J. 24:3210-3221, 2010.